Late Nite With Ed Moore III was first introduced in the spring of 2011 as a Hip/Hop, R&B and Gospel music show, planned with limited commercials and little or no dialogue in between playlists. However, as different formats for the show were thoroughly reviewed and discussed, it was in May of 2011 when the decision was made to execute the show as an educative, self help, talk show geared towards the idea of human interest stories and humanitarianism. Through the assistance of Former WLJS Program Director, Thad Burton and Former WLJS Director of Production, Billy Ramsey, extensive work went underway throughout the summer of 2011 to create a university based radio talk show with a format appropriate for a more national audience.
On Friday, September 9, 2011,Late Nite With Ed Moore III unveiled itself to the world with its live world premiere show on HIV/AIDS awareness, aired from the Communications building on the campus of Jacksonville State University in Jacksonville, Alabama, a location where it continues its broadcast to this day. With the appearance of over 35 guests throughout a twelve week run of its first season, Late Nite With Ed Moore III captured audiences everywhere, becoming a phenomenal success during late Friday nights of radio land. With hundreds of listeners tuned in throughout the premiere season, Late Nite With Ed Moore III broke the barriers of university talk radio by revealing the opportunity for an adjustment in the "status quo" of college based radio talk shows. At the beginning of season two, the show shifted directions towards the journalistic arena, becoming a more news and current event based platform. As a result, the show began reaching broadened listenership throughout its production covering topics such as sexual assault, post 9/11 discrimination towards the Muslim community as well as the struggles of the blind and visually impaired. The show also went on to cover groundbreaking stories which included the death of Whitney Houston, the hazing death of Florida A&M University student, Robert Champion and the February 2012 killing of Florida teenager, Trayvon Martin. In April of 2012, almost a year after the show came into creation, Late Nite With Ed Moore III was awarded the WLJS "People's Choice Award" for its excellence in executing media professionalism as well as diverse listenership.
After three seasons, Late Nite With Ed Moore III aired its last episode on November 30, 2012.